| 王 丹1, 鄢小燕1, 彭明友 1, 張 雄1, 王建塔1, 湯 磊1, 晏 英1,2* |
| 1. 貴州醫科大學 藥學院, 貴州省化學合成藥物研發利用工程技術研究中心, 貴陽 550004;2. 貴州醫科大學 醫藥衛生管理學院, 貴陽 550025 |
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| 摘要: |
| 為明確鷓鴣花枝葉的化學物質基礎,該研究采用硅膠柱色譜、MCI、C18、Sephadex LH-20及制備HPLC等色譜技術對其進行分離和純化,并通過理化性質和波譜數據鑒定化合物的結構。結果表明:(1)從鷓鴣花枝、葉的甲醇提取物中分離得到6個單體化合物,分別鑒定為新化合物8-O-4'-木脂素,即heynealigan A(1)、3β,21-dihydroxy-24-methylenecycloartane(2)、3-oxo-threo-23,24,25-trihydroxytirucall-7-ene(3)、16-dehydeoxy-23β-hydroxymeliasenin F(4)、ergost-5, 24(28)-diene-3β, 23S-diol(5)、7α-羥基谷甾醇(6)。(2)化合物1為新的木脂素,化合物2-4為三萜化合物,化合物5和化合物6為甾體化合物,化合物2-5為首次從該植物中分離得到。該研究結果為鷓鴣花的合理開發利用提供了科學依據。 |
| 關鍵詞: 鷓鴣花, 化學成分, 分離純化, 結構鑒定, 8-O-4'-木脂素 |
| DOI：10.11931/guihaia.gxzw202203006 |
| 分類號:Q946 |
| 文章編號:1000-3142(2023)01-0126-06 |
| 基金項目:國家自然科學基金(31760089); 貴州醫科大學學術新苗項目(19NSP083)。 |
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| A new lignan from Heynea trijuga |
| WANG Dan1, YAN Xiaoyan1, PENG Mingyou1, ZHANG Xiong1, WANG Jianta1, TANG Lei1, YAN Ying1,2* |
| 1. Engineering Technology Research Center for Chemical Drug R &2.D, College of Pharmacy, Guizhou Medical University, Guiyang 55004, China;3.2. College of Medicine and Health Administration, Guizhou Medical University, Guiyang 550025, China |
| Abstract: |
| In order to study the chemical constituents from the branches and leaves of Heynea trijuga, silica gel, MCI, C18, Sephadex LH-20 and preparative HPLC were applied for the isolation and purification of the constituents. The structures were identified by physicochemical properties and spectrum data. The results were as follows:(1)Six compounds were obtained from methanol extracts of H. trijuga, their structures were identified as heynealigan A(1), 3β,21-dihydroxy-24-methylenecycloartane(2), 3-oxo-threo-23,24,25-trihydroxytirucall-7-ene(3), 16-dehydeoxy-23β-hydroxyliasenin F(4), ergost-5, 24(28)-diene-3β, 23S-diol(5), 7α-hydrositosteol(6).(2)Compound 1 was a new lignan, compounds 2-4 were triterpenoids, compounds 5 and 6 were steroids, and compounds 2-5 were isolated from this plant for the first time. This study provides scientific basis for the rational development and utilization of T. connaroides. |
| Key words: Heynea trijuga, chemical constituents, isolation and purification, structural identification, heynealigan A |
鷓鴣花中一個新的木脂素.pdf
